Naproxen, like all nonsteroidal anti-inflammatory drugs (NSAIDs), may exacerbate hypertension and congestive heart failure and may cause an increased risk of serious cardiovascular thromboembolism, myocardial infarction, and stroke, which can be fatal. OTHER NSAIDS. More than 900 OTC and prescription medicines contain an NSAID. Taking naproxen sodium in addition to frequent chronic use of other NSAIDs can increase the risk of GI bleeding, cardiovascular problems, and other serious side effects 2. TREXIMET (sumatriptan/naproxen sodium) is a prescription treatment approved by the FDA for acute treatment of migraine attacks, with or without aura, in adults. Learn how TREXIMET may help your patients. Naproxen sodium is an odorless crystalline powder, white to creamy in color. It is soluble in methanol and water. Naproxen sodium extended-release tablets contain 412.5 mg, 550 mg, or 825 mg of naproxen sodium, equivalent to 375 mg, 500 mg, and 750 mg of naproxen, and 37.5 mg, 50 mg, and 75 mg sodium respectively. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body. Naproxen is used to treat pain or inflammation caused by conditions such as arthritis, ankylosing spondylitis, tendinitis, bursitis, gout, or menstrual cramps. Your dose of naproxen will depend on which brand and strength you take, which condition is being treated, and your age. For arthritis, common dosages can range from 500 to 1,000 milligrams (mg). Explains the medication naproxen (Aleve, Naprosyn, Anaprox, Naprelan) a drug used for the management of mild to moderate pain, fever, and inflammation. Article includes descriptions, uses, drug interactions, and side effects. Read more about naproxen (Aleve, Naprosyn, Anaprox, Naprelan). Prescription naproxen oral tablets may cause drowsiness. You shouldn’t drive, use machinery, or do other activities that require alertness until you know you can function normally. Can Aleve cause allergic reactions? Yes. If you have ever had hives, facial swelling, asthma (wheezing), shock, rash, skin reddening or blisters after taking a pain reliever or fever reducer, do not take Aleve. Prescription naproxen is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), juvenile arthritis (a form of joint disease in children), and ankylosing spondylitis.